| dc.creator | Mena, Licet | |
| dc.creator | Sierra, Roxana | |
| dc.creator | Valle, Maikel | |
| dc.creator | Molina, Vivian | |
| dc.creator | Rodriguez, Sandra | |
| dc.creator | Merino, Nelson | |
| dc.creator | Zamora, Zullyt | |
| dc.creator | González, Victor | |
| dc.creator | Medina, Jose Alberto | |
| dc.date | 2019-04-14 | |
| dc.date.accessioned | 2019-04-15T14:50:35Z | |
| dc.date.available | 2019-04-15T14:50:35Z | |
| dc.identifier | http://www.revistas.usach.cl/ojs/index.php/blacpma/article/view/3847 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/34896 | |
| dc.description | The aim of this study was to evaluate the effects of single oral doses of D-005 (a lipid extract obtained from the fruit oil of Acrocomia crispa) on LPS-induced acute lung injury (ALI) in mice. D-005 batch composition was: lauric (35.8%), oleic (28.4%), myristic (14.2%), palmitic (8.9%), stearic (3.3%), capric (1.9%), caprylic (1.2%), and palmitoleic (0.05%) acids, for a total content of fatty acids of 93.7%. D-005 (200 mg/kg) significantly reduced lung edema (LE) (≈ 28% inhibition) and Lung Weight/Body Weight ratio (LW/BW) (75.8% inhibition). D-005 (25, 50, 100 and 200 mg/kg) produced a significant reduction of Histological score (59.9, 56.1, 53.5 and 73.3% inhibition, respectively). Dexamethasone, as the reference drug, was effective in this experimental model. In conclusion, pretreatment with single oral doses of D-005 significantly prevented the LPS-induced ALI in mice. | es-ES |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Universidad de Santiago de Chile | es-ES |
| dc.relation | http://www.revistas.usach.cl/ojs/index.php/blacpma/article/view/3847/26003060 | |
| dc.source | Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas; Vol 18, No 1: BLACPMA, Enero 2019; 16 - 26 | es-ES |
| dc.source | 0717-7917 | |
| dc.title | Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
