| dc.creator | Saqib, Fatima | |
| dc.creator | Jabeen, Naila | |
| dc.creator | Riaz, Muhammad | |
| dc.creator | Sechel, Gabriela | |
| dc.date | 2019-04-14 | |
| dc.date.accessioned | 2019-04-15T14:50:38Z | |
| dc.date.available | 2019-04-15T14:50:38Z | |
| dc.identifier | http://www.revistas.usach.cl/ojs/index.php/blacpma/article/view/3861 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/34908 | |
| dc.description | To explore the mechanistic basis behind smooth muscle relaxant prospective of Bismarckia nobilis in gastrointestinal, respiratory and cardiovascular ailments. The methanolic extract of B. nobilis and sub-fractions have been evaluated in vitro rabbit isolated tissues, in vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice. The B. nobilis extract relaxed spontaneous and K+ (80 mM)- induced contractions in rabbit isolated jejunum preparations, CCh (1 μM) and K+ (80 mM)-induced contractions in tracheal and bladder preparations, PE (1 μM) and K+ (80 mM)-induced concentrations in aorta preparations, likewise verapamil. Spasmolytic activity of dichloromethane fraction is stronger as compared to aqueous fraction. In vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice further supported spasmolytic activity. B. nobilis extract possess anti-spasmodic, anti-diarrheal, airway relaxant and vasodilator activities possible mediated through calcium channel blocking mechanism, justifying therapeutic utility of B. nobilis in diarrhea, asthma and hypertension. | es-ES |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Universidad de Santiago de Chile | es-ES |
| dc.relation | http://www.revistas.usach.cl/ojs/index.php/blacpma/article/view/3861/26003072 | |
| dc.source | Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas; Vol 18, No 2: BLACPMA, Marzo 2019; 204 - 222 | es-ES |
| dc.source | 0717-7917 | |
| dc.title | Evaluation of smooth muscle relaxant potential of Bismarckia nobilis (Hildebr. & Wendl.) in diarrhea, hypertension and asthma by ex-vivo and in-vivo method | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
