Validez de tres métodos de inmuno-diagnóstico de neurocisticercosis: revisión sistemática de la literatura con meta-análisis 1960-2014
Cardona-Arias, Jaiberth Antonio
Carrasquilla-Agudelo, Yoneida Elena
Restrepo-Posada, Deisy Cristina
Introduction: The screening of neurocysticercosis is complex and immunological methods have varying validity.Objective: To evaluate the validity of ELISA for antigen and antibody, and EITB for antibody in the screening of neurocysticercosis.Methods: Meta-analysis of diagnostic tests with an ex-ante protocol implemented in fivedata-bases with 15 search strategies, ensuring reproducibility in the selection and extraction of information. Sensitivity, specificiy, likelihood ratios (LR), diagnostic odds ratio and ROC curve were estimated in MetaDiSc, and predictive values, and Youden index were estimated in Epidat.Results: EITB presented sensitivity of 85.7% (95% CI 83.5-87.7), specificity93.9% (95% CI = 92.7-95.0), PLR 19.6 (95% CI = 8,6-44.6), NLR 0.16 (95% CI = 0.12-0.21), OR diagnostic 136.2 (95% CI = 54.7-342.6) and area under the curve 0.926. In ELISA for antibody sensitivity was 87.5% (95% CI = 86.1-88.8), specificity92.2% (95% CI = 91.4-93.0), PLR 11.3 (95% CI = 8.45-15.11), NLR 0.15 (95% CI = 0.13-0.18), diagnostic OR 87.4 (95% CI = 60.1-127.1) and area under the curve 0.950. ELISA for antigen showed low diagnostic validity. No differenceswere found in these parameters by sample, antigen or antibody type.Conclusion: ELISA for antibodies and EITB have a similar diagnostic value, detection of serum and CSF showed a similar validity.