| dc.contributor | | es-ES |
| dc.creator | Osorio, Johanna | |
| dc.creator | Barreto, Jackeline | |
| dc.creator | Samboni, Claudia F. | |
| dc.creator | Cándelo, Lina A. | |
| dc.creator | Álvarez, Luis C. | |
| dc.creator | Benavidez, Susana | |
| dc.creator | Téllez, Roso P. | |
| dc.creator | Santofimio, Dagoberto | |
| dc.creator | Ramos, Jorge A. | |
| dc.creator | Gomez, Carlos A. | |
| dc.date | 2017-03-31 | |
| dc.date.accessioned | 2019-04-16T14:41:23Z | |
| dc.date.available | 2019-04-16T14:41:23Z | |
| dc.identifier | http://revinf.cl/index.php/revinf/article/view/1 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/40742 | |
| dc.description | Background: The rise of infections caused by multidrug-resistant Gram negative bacilli (MDR-GNB), added to paucity of newer therapy, have led to increase polymyxin B use, despite adverse renal toxicity profile.Aim: To determine the incidence and risk factors associated to acute kidney injury (AKI) and polymyxin B use, in patients with infections caused by MDR-GNB.Methods: A retrospective cohort, with a nested case-control study of adults who received polymyxin B for more than 48 hours at a tertiary university hospital in Colombia (2011-2015) was performed. AKI was definedby AKIN criteria. Results: Of 139 patients included in our study, 102 were male with median age of 49 years (IQR:28-64). Sixty-one patients (44%) developed AKI. Independent risk factors for development of AKI included: total polymyxin B daily dose (OR = 2.19, 95% CI, 1.04-4.64); length of stay at ICU (OR = 1.03, 95% CI, 1.00-1.06); nosocomial infection (OR = 6.43, 95% CI, 2.12, -19.47); and vasopressor use (OR = 5.38, 95% CI, 2.40-12.07). Mortality was higher among AKI-patients (58.6%) compared with non-AKI patients (25.6%) (p = 0.001). Conclusion: In this study, the rate of AKI associated to polymyxin B use was greater than reported in studies from last decade, and associated with increased mortality. AKI associated to polymyxin B use is likely multifactorial and aggravated by the critically ill state of patients sufferingnosocomial infections caused by mdr-gnb. | es-ES |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Sociedad Chilena de Infectología | es-ES |
| dc.relation | http://revinf.cl/index.php/revinf/article/view/1/1 | |
| dc.rights | Copyright (c) 2017 Revista Chilena de Infectología | es-ES |
| dc.source | Revista Chilena de Infectología; Vol. 34, Núm. 1 (2017) | es-ES |
| dc.source | 0717-6341 | |
| dc.source | 0716-1018 | |
| dc.subject | Antimicrobianos | es-ES |
| dc.subject | Injuria renal; polimixina B; bacilos gramnegativos multi-resistentes | es-ES |
| dc.title | Factores asociados a nefrotoxicidad por polimixina B en un hospital universitario de Neiva, Colombia. 2011-2015 | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | | en-US |
| dc.type | | es-ES |
