Epidemiology and risk factors for prolonged hospital length of stay in children with leukemia and bacteremia. Cohort study
Epidemiología y factores de riesgo de internación prolongada en niños con leucemia y bacteriemia. Estudio de cohorte
| dc.contributor | en-US | |
| dc.contributor | es-ES | |
| dc.creator | Taicz, M., Moira | |
| dc.creator | Pérez, Guadalupe | |
| dc.creator | Reijtman, Vanesa | |
| dc.creator | Mastroianni, Alejandra | |
| dc.creator | Escarra, M., Florencia | |
| dc.creator | García, Eva | |
| dc.creator | Varela, Ana Nina | |
| dc.creator | Guitter, Myriam | |
| dc.creator | Romero, Juana | |
| dc.creator | Ghibaudi, Guillermo | |
| dc.creator | Gómez, Sandra | |
| dc.creator | Bologna, Rosa | |
| dc.date | 2018-07-16 | |
| dc.date.accessioned | 2019-04-16T14:41:31Z | |
| dc.date.available | 2019-04-16T14:41:31Z | |
| dc.identifier | http://revinf.cl/index.php/revinf/article/view/112 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/40793 | |
| dc.description | Introduction: Bacteremia is a frequent complication in children with cancer, which is associated with greater severity, prolonged hospitalization and mortality. Prolonged hospitalization conditions greater morbidity and risk of acquisition of intranosocomial infections. Aim: To describe risk factors for prolonged hospital length of stay in children with leukemia and bacteremia. Methods: Cohort study. Episodes of bacteremia in patients with leukemia at Garrahan Hospital from 1/1/2015 to 31/12/2016 were reviewed. We compared data from patients with a LOS of 14 days or more with those admitted for less than 14 days. Bivariate and logistic regression analysis was performed. We used Stata 13 statistical package. Results: n = 121. Median age 59 months.81 patients (67%) had a diagnosis of acute lymphoblastic leukemia, followed by acute myeloid leukemia in 40 (33%). 96 patients (79%) had a central venous catheter (CVC), 94 patients (78%) were neutropenic. Blood cultures were positive for Enterobacteriaceae in 55 cases (45%), coagulase-negative staphylococci in 28 cases (23%), Group viridans Streptococcus in 19 (16%), Pseudomonas aeruginosa in 8 (7%). (9%). By the multivariate analysis, three factors remained significantly associated with length of stay of more than 14 days: CVC associated bacteremia (OR 21,73; CI95% 1.2- 43.2; p 0.04), severe neutropenia (OR 1.75; CI95% 1.82-1.28; p 0.03) and coinfection (OR 27.4; CI95% 2.8-260.8; p 0.004). Conclusion: CVC associated bacteremia, severe neutropenia and viral coinfection were associated with hospital LOS of more than 14 days. | en-US |
| dc.description | Introducción: La bacteriemia constituye una complicacion frecuente en los niños con cáncer, que se asocia a mayor gravedad, internación prolongada y mortalidad. La internación prolongada condiciona mayor morbilidad y riesgo de adquisición de infecciones intranosocomiales. Objetivo: Analizar factores de riesgo de internación prolongada en niños con leucemia y bacteriemia. Pacientes y Métodos: Cohorte retrospectiva. Se incluyeron niños con leucemia internados en el Hospital Garrahan entre 1/1/2015 y 31/12/2016 con bacteriemia. Se compararon características de pacientes con internaciones menores o mayores a 14 días. Se realizó un análisis bivariado y modelo de regresión logística. Se utilizó Stata 13. Resultados: n = 121. Mediana de edad 59 meses. Tenían leucemia linfoblastica 81 pacientes (67%) y leucemia mieloblástica 40 (33%). Tenían catéter venoso central (CVC) 96 de los niños (79%), neutropenia 94 (78%), neutropenia menor a 100 neutrófilos 79 (65%). La identificación en hemocultivos fue: 55 casos (45%) enterobacterias, 28 (23%) Staphylococcus coagulasa negativa, Streptococcus spp grupo viridans 19 (16%), Pseudomonas aeruginosa 8 (7%). Huo co-infección viral en 14 pacientes (12%).Tuvieron menos de 14 días de internación 71 pacientes (59%) y mayor período 50 (41%). En el análisis multivariado la bacteriemia asociada a CVC (OR 21,73; IC95% 1,2-43,20; p 0,04), neutropenia profunda al ingreso (OR 1,75; IC95% 1,82-1,28; p 0,03) y co-infección viral (OR 27,42; IC95% 2,88-260,83; p 0,004) fueron factores de riesgo de internación > 14 días. Conclusiones: La bacteriemia asociada a CVC, la neutropenia profunda al ingreso y la co-infección se asociaron con una internación igual o mayor a 14 días. | es-ES |
| dc.format | ||
| dc.language | spa | |
| dc.publisher | Sociedad Chilena de Infectología | es-ES |
| dc.relation | http://revinf.cl/index.php/revinf/article/view/112/58 | |
| dc.rights | Copyright (c) 2018 Revista Chilena de Infectología | es-ES |
| dc.rights | https://creativecommons.org/licenses/by-sa/4.0 | es-ES |
| dc.source | Revista Chilena de Infectología; Vol. 35, Núm. 3 (2018): Junio | es-ES |
| dc.source | 0717-6341 | |
| dc.source | 0716-1018 | |
| dc.subject | Clinical Research | en-US |
| dc.subject | Cancer; bacteremia; children | en-US |
| dc.subject | Investigación Clínica | es-ES |
| dc.subject | Cáncer; bacteriemia; niños | es-ES |
| dc.title | Epidemiology and risk factors for prolonged hospital length of stay in children with leukemia and bacteremia. Cohort study | en-US |
| dc.title | Epidemiología y factores de riesgo de internación prolongada en niños con leucemia y bacteriemia. Estudio de cohorte | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | es-ES | |
| dc.type | es-ES | |
| dc.type | en-US | |
| dc.type | en-US |
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Revista Chilena de Infectología
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