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Remarks on the possibility of introducing the fractionated dose of the inactivated poliomyelitis vaccine in the Latin American Child Immunization Schedule*

Consideraciones referente a la posibilidad de introducir la dosis fraccionada de la vacuna antipoliomielitis inactivada en el calendario de Inmunizaciones del Niño Latinoamericano

dc.contributoren-US
dc.contributores-ES
dc.creatorArbo, Antonio
dc.creatorFalleiros-Arlant, Luiza Helena
dc.creatorL. López, Eduardo
dc.creatorBrea del Castillo, José
dc.creatorMartínez de Cuellar, Celia
dc.creatorMoreno, Gabriela
dc.creatorRolón, Roger
dc.creatorCerda, Javier
dc.creatorEguiazú, Salim
dc.date2019-04-05
dc.date.accessioned2019-04-16T14:41:33Z
dc.date.available2019-04-16T14:41:33Z
dc.identifierhttp://revinf.cl/index.php/revinf/article/view/389
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/40809
dc.descriptionGiven that the last notified case of poliomyelitis due to wild poliovirus type 2 was in 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of a bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules. The introduction of IPV prior to the change of the bOPV in 2016 to trivalent OPV (tOPV) was based on the concept of ensuring that a substantial proportion of the population would be protected against type 2 polio after the removal of the type 2 OPV. However, the world’s two producers of IPV (Bilthoven Biologicals and Sanofi) have faced problems in the production of this vaccine and therefore reported a reduction of the global supply of IPV. In response to the potential shortage of IPV, at a meeting held on March 10 2017, the SAGE and Technical Advisory Group (TAG) of the Pan American Health Organization (PAHO) urged the countries in the Latin American region to replace the routine administration of the full doses of inactivated polio vaccine (IPV-C) in the immunization schedule (administered by intramuscular route), administering a fraction of the full dose in two intradermal shots (IPV-f). The possibility of this strategy was analyzed by opinion leaders convened by the Paraguayan Society of Pediatrics with the support of the Latin American Society of Pediatric Infectious Diseases (SLIPE) and Latin American Association of Pediatrics (ALAPE). This document presents the results of the discussion.en-US
dc.descriptionGiven that the last notified case of poliomyelitis due to wild poliovirus type 2 was in 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of a bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules. The introduction of IPV prior to the change of the bOPV in 2016 to trivalent OPV (tOPV) was based on the concept of ensuring that a substantial proportion of the population would be protected against type 2 polio after the removal of the type 2 OPV. However, the world’s two producers of IPV (Bilthoven Biologicals and Sanofi) have faced problems in the production of this vaccine and therefore reported a reduction of the global supply of IPV. In response to the potential shortage of IPV, at a meeting held on March 10 2017, the SAGE and Technical Advisory Group (TAG) of the Pan American Health Organization (PAHO) urged the countries in the Latin American region to replace the routine administration of the full doses of inactivated polio vaccine (IPV-C) in the immunization schedule (administered by intramuscular route), administering a fraction of the full dose in two intradermal shots (IPV-f). The possibility of this strategy was analyzed by opinion leaders convened by the Paraguayan Society of Pediatrics with the support of the Latin American Society of Pediatric Infectious Diseases (SLIPE) and Latin American Association of Pediatrics (ALAPE). This document presents the results of the discussion.es-ES
dc.format
dc.languagespa
dc.publisherSociedad Chilena de Infectologíaes-ES
dc.relationhttp://revinf.cl/index.php/revinf/article/view/389/155
dc.rightsCopyright (c) 2019 Revista Chilena de Infectologíaes-ES
dc.rightshttps://creativecommons.org/licenses/by-sa/4.0es-ES
dc.sourceRevista Chilena de Infectología; Vol. 36, Núm. 1 (2019): Febreroes-ES
dc.source0717-6341
dc.source0716-1018
dc.subjecten-US
dc.subjectinactivated poliomyelitis vaccine; poliomyelitis;vaccineen-US
dc.subjectes-ES
dc.subjectvacuna contra la poliomielitis inactivada; poliomielitis; vacunaes-ES
dc.titleRemarks on the possibility of introducing the fractionated dose of the inactivated poliomyelitis vaccine in the Latin American Child Immunization Schedule*en-US
dc.titleConsideraciones referente a la posibilidad de introducir la dosis fraccionada de la vacuna antipoliomielitis inactivada en el calendario de Inmunizaciones del Niño Latinoamericanoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US
dc.typeen-US
dc.typees-ES
dc.typees-ES


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