Trend in Tuberculosis (TB) rates and association of factors affecting the outcome of this disease were assessed in the Health Service of Viña del Mar-Quillota, Chile from 1999 to 2008. Study of 1291 TB patients by the years 1999 to 2008. We evaluated incidence and mortality rate per 100,000 inhabitants, pulmonary / extrapulmonary ratio, presence of HIV, death and site of infection. It was found a decreasing trend in the incidence rate (p < 0.001 R² = 0.97) and association between the presence of HIV and case fatality rate (p < 0.001). It was not found association between site of disease and mortality rate (p = 0.3) nor a decreasing trend in mortality (p = 0.116) and pulmonary/extrapulmonary ratio (p = 0.194). There is a decreasing trend in the incidence rate of TB patients which reflects a well-functioning system of control and surveillance; the presence of HIV is associated with death because of this it should be considered in clinical management of TB.Se evalúa la tendencia de las tasas de incidencia de tuberculosis (TBC) y de factores asociados al desenlace de esta enfermedad, en el Servicio de Salud Viña del Mar-Quillota durante los años 19992008. Estudio de 1.291 pacientes con TBC entre los años 1999-2008. Se evalúa tasa de incidencia y mortalidad por 100.000 habitantes, razón de casos pulmonares/extrapulmonares, presencia de VIH, tasa de letalidad y localización de la infección. Se observa una tendencia decreciente en la tasa de incidencia (p