Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas
Author
Gordón-Núñez,Manuel Antonio
Godoy,Gustavo Pina
Soares,Rosilene Calazans
Souza,Lélia Batista de
Freitas,Roseana de Almeida
Queiroz,Lélia María Guedes
Abstract
The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins. It was observedweak labeling for p53 in 12 cases (63.1%) andforPCNA in 8 (42.1%). With respect to the bcl-2 labeling index,ono expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably doesonot effectively particípate in the pathogenesis of this tumor.