Honey is a natural product with many attributes that are useful for humans. The consumption of honey is increasing because of its beneficial biological properties, including antioxidant and antibacterial activities. Even though honey is produced worldwide, many variants of this product have not been studied and their biological potential for alternative uses has not been evaluated. Because of its varied endemic native flora, Chile produces several types of honey. It is likely that these apian products have important biological properties inherited from specific floral sources, but it is absolutely necessary to conduct further chemical analyses to identify and characterize these biological attributes. Sadly, the potential antimicrobial and antitumor activities of Chilean honeys remain unproven at the present time. Further studies are needed to identify these attributes. In addition, the impact of human activities on the natural production of honey by bees should be considered. The use of honey as an environmental marker of pollution should also be considered, and care must be taken to diminish the effect of industry and human procedures on natural environments