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Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee

Author
González-Alvarez,Rafael

Garza-Rodriguez,María de Lourdes

Delgado-Enciso,Iván

Treviño-Alvarado,Victor Manuel

Canales-Del-Castillo,Ricardo

Martínez-De-Villarreal,Laura Elia

Lugo-Trampe,Ángel

Tejero,María Elizabeth

Schlabritz-Loutsevitch,Natalia E.

Rocha-Pizaña,María Del Refugio

Cole,Shelley A.

Reséndez-Pérez,Diana

Moises-Alvarez,Mario

Comuzzie,Anthony G.

Barrera-Saldaña,Hugo Alberto

Garza-Guajardo,Raquel

Barboza-Quintana,Oralia

Rodríguez-Sánchez,Irám Pablo

Full text
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100031
Abstract
BACKGROUND: Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. RESULTS: RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. CONCLUSIONS: RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.
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Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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