Show simple item record

Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee

dc.creatorGonzález-Alvarez,Rafael
dc.creatorGarza-Rodriguez,María de Lourdes
dc.creatorDelgado-Enciso,Iván
dc.creatorTreviño-Alvarado,Victor Manuel
dc.creatorCanales-Del-Castillo,Ricardo
dc.creatorMartínez-De-Villarreal,Laura Elia
dc.creatorLugo-Trampe,Ángel
dc.creatorTejero,María Elizabeth
dc.creatorSchlabritz-Loutsevitch,Natalia E.
dc.creatorRocha-Pizaña,María Del Refugio
dc.creatorCole,Shelley A.
dc.creatorReséndez-Pérez,Diana
dc.creatorMoises-Alvarez,Mario
dc.creatorComuzzie,Anthony G.
dc.creatorBarrera-Saldaña,Hugo Alberto
dc.creatorGarza-Guajardo,Raquel
dc.creatorBarboza-Quintana,Oralia
dc.creatorRodríguez-Sánchez,Irám Pablo
dc.date2015-01-01
dc.date.accessioned2019-05-02T21:22:27Z
dc.date.available2019-05-02T21:22:27Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100031
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82538
dc.descriptionBACKGROUND: Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. RESULTS: RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. CONCLUSIONS: RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.1186/S40659-015-0020-0
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.48 2015
dc.subjectRetinoic acid receptor
dc.subjectResponder protein
dc.subjectPrimate
dc.subjectChemerin
dc.subjectTIG2
dc.subjectTazarotene-induced gene 2 protein
dc.subjectGene expression
dc.titleMolecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee


This item appears in the following Collection(s)

Show simple item record