We used a bio-economic model to analyze the role that alternative seeding-harvesting schedules, temperature, dissolved oxygen, stocking density, and duration of cultivation play in the economic performance of semi-intensive shrimp cultivation in Mexico. The highest production was predicted for the May-August schedule (1130-2300 kg ha-1), while the lowest yields were obtained for the March-June schedule (949-1300 kg ha-1). The highest net revenues were projected for the August-November schedule (US$354-1444 ha-1), while the lowest was projected for the May-August schedule (US$330-923 ha-1). The highest annual net revenues were predicted for the combination of the March-June and August-November schedules (US$1432-2562 ha-1). Sensitivity analysis indicated temperature and dissolved oxygen were the most important factors determining net revenues in March-June schedule. For the May-August and August-November schedules, stocking density was the most important factor. Duration of cultivation was the least sensitive variable. Break-even production analysis confirmed that the combination of the March-June and August-November schedules were more efficient from an economic perspective. We recommend test some ponds with higher stocking density in the March-June and August-November schedules, and in the latter case, seeding in June or July rather than August.