In Mexico, as in many other Latin American countries, the lack of a development plan and/or prevention in aquaculture to environmental variability is evident. In the State of Colima, aquaculture presents lags in terms of technical and productive capacity especially for growing tilapia Oreochromis spp. Surveys were performed to farmers and experts, in addition to consulting scientific literature sources, and identifying different risk factors arising from the practice of aquaculture in order to assess the vulnerability of the sector. The main risk factor associated with hydrometeorological phenomena, for which the need to define high-risk areas, even more, given the uncertainty of the same due to global climate change is recognized. This study proposes to implement a comprehensive program of technological conversion and control measures for alien species that also consider aquaculture production schemes based on the efficient use of water, and to consider using this endemic species for cultivation.