Cuantificación de esteatosis hepática no alcohólica por resonancia magnética

QUANTIFICATION OF LIVER FAT INFILTRATION BY MAGNETIC RESONANCE

Author
Herrera, Rodrigo; pontificia universidad catolica de chile

Peñaloza, Francisco; pontificia universidad catolica de chile

Arrieta, Cristóbal; pontificia universidad catolica de chile

Zacconi, Flavia; pontificia universidad catolica de chile

Saavedra, Víctor; centro de estudios clinicos e investigacion medica (CECIM)

Saavedra, Carla; centro de estudios clinicos e investigacion medica (CECIM)

Brañes, Cecilia; Naturalis sa

Hack, Thomas; naturalis sa

Uribe, Sergio; pontificia universidad catolica de chile

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/7105
Abstract
Background: A simple and inexpensive method is required to assess fatty infiltration of the liver non-invasively. Aim: To develop and compare different methods to quantify liver fat by magnetic resonance and compare it against ultrasound. Material and methods: Three algorithms were implemented: region growing (RG), graph cuts (GC) and hierarchical (HR), all based on the IDEAL method to obtain water and fat images. _Using these images, the proton density fat fraction (PDFF) was calculated. The three methods were tested in phantoms with known fat percentages and later on we acquired images from 20 volunteers with an ultrasound diagnosis of fatty liver disease in different stages. For everyone, the PDFF of the nine liver segments was determined. Results: In phantoms, the mean error between the real fat percentage and the value obtained through the three methods was -1,26, -1 and -0,8 for RG, GC and HR respectively. The hierarchical method was more precise and efficient to obtain PDFF. The results in volunteers revealed that ultrasound showed errors categorizing the severity of hepatic steatosis in more than 50% of volunteers. Conclusions: We developed a tool for magnetic resonance, which allows to quantify fat in the liver. This method is less operator dependent than ultrasound and describes the heterogeneity in the fat distribution along the nine hepatic segments.
 
Background: A simple and inexpensive method is required to assess fatty infiltration of the liver non-invasively. Aim: To develop and compare different methods to quantify liver fat by magnetic resonance and compare it against ultrasound. Material and methods: Three algorithms were implemented: region growing (RG), graph cuts (GC) and hierarchical (HR), all based on the IDEAL method to obtain water and fat images. _Using these images, the proton density fat fraction (PDFF) was calculated. The three methods were tested in phantoms with known fat percentages and later on we acquired images from 20 volunteers with an ultrasound diagnosis of fatty liver disease in different stages. For everyone, the PDFF of the nine liver segments was determined. Results: In phantoms, the mean error between the real fat percentage and the value obtained through the three methods was -1,26, -1 and -0,8 for RG, GC and HR respectively. The hierarchical method was more precise and efficient to obtain PDFF. The results in volunteers revealed that ultrasound showed errors categorizing the severity of hepatic steatosis in more than 50% of volunteers. Conclusions: We developed a tool for magnetic resonance, which allows to quantify fat in the liver. This method is less operator dependent than ultrasound and describes the heterogeneity in the fat distribution along the nine hepatic segments.
 
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