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Cuantificación de esteatosis hepática no alcohólica por resonancia magnética

QUANTIFICATION OF LIVER FAT INFILTRATION BY MAGNETIC RESONANCE

dc.contributorCECIM, NATURALIS SAes-ES
dc.contributoren-US
dc.creatorHerrera, Rodrigo; pontificia universidad catolica de chile
dc.creatorPeñaloza, Francisco; pontificia universidad catolica de chile
dc.creatorArrieta, Cristóbal; pontificia universidad catolica de chile
dc.creatorZacconi, Flavia; pontificia universidad catolica de chile
dc.creatorSaavedra, Víctor; centro de estudios clinicos e investigacion medica (CECIM)
dc.creatorSaavedra, Carla; centro de estudios clinicos e investigacion medica (CECIM)
dc.creatorBrañes, Cecilia; Naturalis sa
dc.creatorHack, Thomas; naturalis sa
dc.creatorUribe, Sergio; pontificia universidad catolica de chile
dc.date2019-07-17
dc.date.accessioned2019-11-11T18:26:44Z
dc.date.available2019-11-11T18:26:44Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/7105
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110801
dc.descriptionBackground: A simple and inexpensive method is required to assess fatty infiltration of the liver non-invasively. Aim: To develop and compare different methods to quantify liver fat by magnetic resonance and compare it against ultrasound. Material and methods: Three algorithms were implemented: region growing (RG), graph cuts (GC) and hierarchical (HR), all based on the IDEAL method to obtain water and fat images. _Using these images, the proton density fat fraction (PDFF) was calculated. The three methods were tested in phantoms with known fat percentages and later on we acquired images from 20 volunteers with an ultrasound diagnosis of fatty liver disease in different stages. For everyone, the PDFF of the nine liver segments was determined. Results: In phantoms, the mean error between the real fat percentage and the value obtained through the three methods was -1,26, -1 and -0,8 for RG, GC and HR respectively. The hierarchical method was more precise and efficient to obtain PDFF. The results in volunteers revealed that ultrasound showed errors categorizing the severity of hepatic steatosis in more than 50% of volunteers. Conclusions: We developed a tool for magnetic resonance, which allows to quantify fat in the liver. This method is less operator dependent than ultrasound and describes the heterogeneity in the fat distribution along the nine hepatic segments.es-ES
dc.descriptionBackground: A simple and inexpensive method is required to assess fatty infiltration of the liver non-invasively. Aim: To develop and compare different methods to quantify liver fat by magnetic resonance and compare it against ultrasound. Material and methods: Three algorithms were implemented: region growing (RG), graph cuts (GC) and hierarchical (HR), all based on the IDEAL method to obtain water and fat images. _Using these images, the proton density fat fraction (PDFF) was calculated. The three methods were tested in phantoms with known fat percentages and later on we acquired images from 20 volunteers with an ultrasound diagnosis of fatty liver disease in different stages. For everyone, the PDFF of the nine liver segments was determined. Results: In phantoms, the mean error between the real fat percentage and the value obtained through the three methods was -1,26, -1 and -0,8 for RG, GC and HR respectively. The hierarchical method was more precise and efficient to obtain PDFF. The results in volunteers revealed that ultrasound showed errors categorizing the severity of hepatic steatosis in more than 50% of volunteers. Conclusions: We developed a tool for magnetic resonance, which allows to quantify fat in the liver. This method is less operator dependent than ultrasound and describes the heterogeneity in the fat distribution along the nine hepatic segments.en-US
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 147, núm. 7 (2019): JULIO 2019es-ES
dc.source0034-9887
dc.subjectFatty Liver; Magnetic Resonance Imaging; Non-alcoholic Fatty Liveres-ES
dc.subjectFatty Liver; Magnetic Resonance Imaging; Non-alcoholic Fatty Liveren-US
dc.titleCuantificación de esteatosis hepática no alcohólica por resonancia magnéticaes-ES
dc.titleQUANTIFICATION OF LIVER FAT INFILTRATION BY MAGNETIC RESONANCEen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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