Proteína C reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades.

Author
Díaz, Orlando; Departamento de Enfermedades Respiratorias, Departamento de Medicina Intensiva. Pontificia Universidad Católica de Chile.

Parada, Alejandra; Departamento de Nutrición, Diabetes y Metabolismo

Ramos, Cristóbal; Departamento de Imagenología. Universidad de Chile

Klaassen, Julieta; Departamento de Nutrición, Diabetes y Metabolismo

Díaz, Juan Carlos; Departamento de Imagenología. Universidad de Chile.

Andresen, Max; Departamento de Medicina Intensiva. Pontificia Universidad Católica de Chile.

Lisboa, Carmen; Departamento de Enfermedades Respiratorias

Saldías, Fernando; Departamento de Enfermedades RespiratoriasDepartamento de Medicina Intensiva. Pontificia Universidad Católica de Chile.

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1244
Abstract
C-REACTIVE PROTEIN LEVELS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMI), fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both  quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COPD patients than in controls (7±4.2 and 3.7±2.7 mg/L respectively; p
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