MICRO-ELECTRODE GUIDED SUBTHALAMIC NUCLEUS STIMULATION IN PARKINSON´S DISEASE. EXPERIENCE IN 20 PATIENTS
Estimulación guiada por electrodos de núcleo subtalámico en enfermedad de Parkinson.
Author
Kunstmann, Carolina; Clínica Alemana de Santiago
Valdivia, Felipe; Clínica Alemana de Santiago
de Marinis, Alejandro; Clínica Alemana de Santiago
Ayach, Fredy; Clínica Alemana de Santiago
Montes, José Miguel; Clínica Alemana de Santiago
Chaná-Cuevas, Pedro; Facultad de Ciencias Medicas
Universidad de Santiago de Chile
Clínica Alemana de Santiago
Abstract
Background: Deep brain stimulation is an essential therapeutic tool in Parkinson´s disease. Aim: To assess the results of a series of patients with Parkinson’s disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson’s disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30±15 to 10±7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17±16 to 78±21%. ON hours with dyskinesia changed from 53±23 to 12±15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson’s disease has good immediate and late results. Background: Deep brain stimulation is an essential therapeutic tool in Parkinson´s disease. Aim: To assess the results of a series of patients with Parkinson’s disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson’s disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30±15 to 10±7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17±16 to 78±21%. ON hours with dyskinesia changed from 53±23 to 12±15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson’s disease has good immediate and late results.
Metadata
Show full item recordRelated items
Showing items related by title, author, creator and subject.
-
CURVAS DE BIOMETRÍA FETAL CON EDAD GESTACIONAL DETERMINADA POR ECOGRAFÍA DE PRIMER TRIMESTRE: CLÍNICA ALEMANA DE SANTIAGO
Astudillo D,Julio; Yamamoto C,Masami; Carrillo T,Jorge; Polanco G,Max; Hernández A,Alfredo; Pedraza S,Daniel; Valentini Ch,París; Valdivia M,Juan; Insunza F,Alvaro. Revista chilena de obstetricia y ginecología v.73 n.4 2008 -
RM de encéfalo sin anestesia en pacientes recién nacidos: Experiencia inicial en Clínica Alemana de Santiago
Sánchez D,Nicolás; Castoldi L,María Francesca; Stecher G,Ximena. Revista chilena de radiología v.20 n.4 2014 -
Menopausia y Terapia Hormonal de la Menopausia Las recomendaciones 2018 de la Unidad de Endocrinología Ginecológica de Clínica Alemana de Santiago -Sociedad Italiana de la Menopausia y la Sociedad Chilena de Endocrinología Ginecológica
Parra,M.; Lagos,N.; Levancini,M.; Villarroel,M.; Pizarro,E.; Vanhauwaert,P,; Velasco,S.; Fernadez,M; Gambacciani,M.; Biglia,N.; Cagnacci,A.; Caruso,S.; Cicinelli,E.; Leo,V. De; Carlo,C. Di; Farris,M.; Gambera,A.; Guaschino,S.; Lanzone,A; Paoletti,AM; Russo,N.; Vicariotto,F.; Villa,P.; Volpe,A.; Lavin,P.; Lopez,M.; Campusano,C.; Barriga,P.; Brantes,S.. Revista chilena de obstetricia y ginecología v.83 n.5 2018