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MICRO-ELECTRODE GUIDED SUBTHALAMIC NUCLEUS STIMULATION IN PARKINSON´S DISEASE. EXPERIENCE IN 20 PATIENTS

Estimulación guiada por electrodos de núcleo subtalámico en enfermedad de Parkinson.

dc.contributoren-US
dc.contributores-ES
dc.creatorKunstmann, Carolina; Clínica Alemana de Santiago
dc.creatorValdivia, Felipe; Clínica Alemana de Santiago
dc.creatorde Marinis, Alejandro; Clínica Alemana de Santiago
dc.creatorAyach, Fredy; Clínica Alemana de Santiago
dc.creatorMontes, José Miguel; Clínica Alemana de Santiago
dc.creatorChaná-Cuevas, Pedro; Facultad de Ciencias Medicas Universidad de Santiago de Chile Clínica Alemana de Santiago
dc.date2018-05-09
dc.date.accessioned2019-11-11T18:26:48Z
dc.date.available2019-11-11T18:26:48Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5851
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110843
dc.descriptionBackground: Deep brain stimulation is an essential therapeutic tool in Parkinson´s disease. Aim: To assess the results of a series of patients with Parkinson’s disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson’s disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30±15 to 10±7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17±16 to 78±21%. ON hours with dyskinesia changed from 53±23 to 12±15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson’s disease has good immediate and late results.en-US
dc.descriptionBackground: Deep brain stimulation is an essential therapeutic tool in Parkinson´s disease. Aim: To assess the results of a series of patients with Parkinson’s disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson’s disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30±15 to 10±7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17±16 to 78±21%. ON hours with dyskinesia changed from 53±23 to 12±15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson’s disease has good immediate and late results.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5851/4001
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28525
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28528
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28529
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28530
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28536
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/28537
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5851/29096
dc.sourceRevista Médica de Chile; Vol. 146, núm. 5 (2018): MAYO 2018es-ES
dc.source0034-9887
dc.subjectDeep Brain Stimulation; Parkinson Disease; Subthalamic Nucleusen-US
dc.subjectDeep Brain Stimulation; Parkinson Disease; Subthalamic Nucleuses-ES
dc.titleMICRO-ELECTRODE GUIDED SUBTHALAMIC NUCLEUS STIMULATION IN PARKINSON´S DISEASE. EXPERIENCE IN 20 PATIENTSen-US
dc.titleEstimulación guiada por electrodos de núcleo subtalámico en enfermedad de Parkinson.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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