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Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts

Antioxidant and anti-cancer activities of Ochrophyta and Rhodophyta extracts from Chilean coasts

Author
Miranda-Delgado, Alejandra

Montoya, María José

Paz-Araos, Marilyn

Mellado, Marco

Villena, Joan

Arancibia, Paulina

Madrid, Alejandro

Jara-Gutiérrez, Carlos

Full text
http://lajar.ucv.cl/index.php/rlajar/article/view/vol46-issue2-fulltext-6
10.3856/vol46-issue2-fulltext-6
Abstract
This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.
 
Abstract This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi.  The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays.  Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN).  The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of these D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective.  Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.  
 
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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