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Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts

Antioxidant and anti-cancer activities of Ochrophyta and Rhodophyta extracts from Chilean coasts

dc.contributorUniversidad de Valparaísoen-US
dc.contributorUniversidad de Valparaísoes-ES
dc.creatorMiranda-Delgado, Alejandra
dc.creatorMontoya, María José
dc.creatorPaz-Araos, Marilyn
dc.creatorMellado, Marco
dc.creatorVillena, Joan
dc.creatorArancibia, Paulina
dc.creatorMadrid, Alejandro
dc.creatorJara-Gutiérrez, Carlos
dc.date2018-05-29
dc.date.accessioned2020-11-05T13:36:17Z
dc.date.available2020-11-05T13:36:17Z
dc.identifierhttp://lajar.ucv.cl/index.php/rlajar/article/view/vol46-issue2-fulltext-6
dc.identifier10.3856/vol46-issue2-fulltext-6
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/159027
dc.descriptionThis study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.en-US
dc.descriptionAbstract This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi.  The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays.  Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN).  The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of these D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective.  Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.  es-ES
dc.formatapplication/pdf
dc.languageeng
dc.publisherPontificia Universidad Católica de Valparaísoen-US
dc.relationhttp://lajar.ucv.cl/index.php/rlajar/article/view/vol46-issue2-fulltext-6/919
dc.sourceLatin American Journal of Aquatic Research; Vol 46, No 2 (2018); 301-313en-US
dc.sourcePlataforma para envío de artículos - Latin American Journal of Aquatic Research; Vol 46, No 2 (2018); 301-313es-ES
dc.source0718-560X
dc.source0718-560X
dc.subjectalgae; antioxidant activity; cytotoxicity; cancer; polyphenols; flavonoids; Chilean coasten-US
dc.subjectAlgae; antioxidant activity; cytotoxicity; cancer; polyphenolses-ES
dc.titleAntioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coastsen-US
dc.titleAntioxidant and anti-cancer activities of Ochrophyta and Rhodophyta extracts from Chilean coastses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US
dc.typees-ES


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