Objective: To characterize the latency time, depth time and total duration time of 4% articaine and 2% lidocaine- both with 1:100,000 epinephrine - during the extraction through odontosection of impacted mandibular third molars by means of a truncal anesthesia technique.Materials and Methods: A cross-sectional descriptive study of case series selected by a non-probabilistic sampling was conducted on 27 subjects who underwent extraction through odontosection of impacted mandibular third molars using either 4% articaine or 2% lidocaine- both with 1:100,000 epinephrine. A procedure related data collection ensued.Results: Total duration time of anesthetic effect showed a statistical significant longer effect when using 4% articaine in comparison with 2% lidocaine. Whereas, neither latency time nor anesthetic depth time showed any statistical significant difference.   Conclusion: 4% articaine provides a greater total duration time of anesthetic effect, so it should be  preferred for long-term procedures, allowing greater post-operative comfort.Objective: To characterize the latency time, depth time and total duration time of 4% articaine and 2% lidocaine- both with 1:100,000 epinephrine - during the extraction through odontosection of impacted mandibular third molars by means of a truncal anesthesia technique.Materials and Methods: A cross-sectional descriptive study of case series selected by a non-probabilistic sampling was conducted on 27 subjects who underwent extraction through odontosection of impacted mandibular third molars using either 4% articaine or 2% lidocaine- both with 1:100,000 epinephrine. A procedure related data collection ensued.Results: Total duration time of anesthetic effect showed a statistical significant longer effect when using 4% articaine in comparison with 2% lidocaine. Whereas, neither latency time nor anesthetic depth time showed any statistical significant difference.   Conclusion: 4% articaine provides a greater total duration time of anesthetic effect, so it should be  preferred for long-term procedures, allowing greater post-operative comfort.Objetivo: Caracterizar los efectos de tiempo de latencia, tiempo de profundidad y tiempo de duración total de articaína al 4% y lidocaína 2% ambas con epinefrina 1:100.000, mediante técnica troncular para la exodoncia con odontosección de terceros molares inferiores incluidos. Materiales y Métodos: Se realizó un estudio descriptivo de tipo de serie de casos transversal seleccionada por un muestreo no probabilístico por conveniencia de 27 sujetos, con terceros molares inferiores incluidos con necesidad de odontosección donde durante el procedimiento hayan utilizado Articaína 4% o Lidocaína al 2%, ambas con epinefrina 1:100.000. Se recopilaron datos en relación al procedimiento. Resultados: El tiempo total de duración del efecto anestésico fue mayor con el uso articaína al 4% versus lidocaína 2%, siendo esto estadísticamente significativo, no así en el tiempo de latencia y el tiempo de profundidad anestésica que no presentaron significancia estadística. Conclusión: La articaína al 4% presenta el mejor tiempo de duración total del efecto anestésico, por lo que sería preferente para procedimientos de larga duración, permitiendo mayor comodidad post-operatoria.