Differential Diagnosis of Proliferative Verrucous Leukoplakia in Tongue: Report of a Case
Diagnóstico Diferencial de Leucoplasia Verrucosa Proliferativa en Lengua: Reporte de un Caso
| dc.creator | Delgado Cruz, Sidfrid | |
| dc.creator | Salazar Anabalón, Isidora | |
| dc.creator | de la Maza Acevedo, Jaime | |
| dc.creator | Pennacchiotti Vidal, Gina | |
| dc.date | 2021-01-18 | |
| dc.date.accessioned | 2022-04-28T14:26:19Z | |
| dc.date.available | 2022-04-28T14:26:19Z | |
| dc.identifier | https://revistas.uv.cl/index.php/asid/article/view/2654 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/181801 | |
| dc.description | Background: Proliferative verrucous leukoplakia (PVL), a rare and aggressive form of oral leukoplakia (OL) of unknown etiology. Associated with tobacco, Human Papillomavirus, and Candida Albicans. It is characterized by progressive multifocal lesions with an inadequate therapeutic response, high recurrence, and a tendency to become malignant. Clinical Presentation: Male patient, 54 years old, systemically healthy, smoker. White lesion on dorsal midtongue, in the posterior 2/3 of the tongue, with a slightly exophytic shape that did not come off when scraping, with defined edges associated with erythematous mucosa. In the right side, in the middle there was another similar lesion. An incisional biopsy: The one located in the right area presented epithelial hyperplasia, covered by a thick layer of keratin, and the one in the left area presented hyperkeratinized epithelium, withering of the basement membrane and of the subepithelial lymphocyte band, resulting in the histopathological diagnosis of hyperkeratosis. Elimination of smoking habits, and periodic controls were indicated. Clinical Relevance: LVP predominantly affects women over 60 years of age. It tends to progress from a single to multifocal lesions distributed over the gingiva, jugal mucosa, alveolar ridge, and tongue, with exophytic growth, a verrucous appearance with keratinized areas. Histology can show a variety of features, from hyperkeratosis in the early stages, acanthosis, and atypia, which can then progress to verrucous hyperplasia, warty carcinoma, and finally squamous cell carcinoma. Currently, there is no effective therapeutic protocol, since it has a high recurrence, making it essential to avoid risk factors and monitor periodically. Conclusion: PVL is a multifocal pathology, with high recurrence and potential for malignancy. Its early diagnosis is essential to carry out an adequate follow-up, in addition to centering its treatment on eliminating risk factors, performing periodic controls, and biopsies. | en-US |
| dc.description | Antecedentes: La leucoplasia verrucosa proliferativa (LVP) es forma rara y agresiva de leucoplasia oral (LO), etiología desconocida. Asociada a tabaco, virus papiloma humano y candida albicans. Caracterizada por lesiones multifocales progresivas, inadecuada respuesta terapéutica, alta recurrencia y tendencia a malignizarse.Presentación Clínica: Hombre, 54 años, sistémicamente sano, fumador. Lesiones linguales blanquecinas. Lesión blanquecina en dorsal de hemilengua izquierda en tercio medio y posterior 4x3cm, forma irregular, levemente exofítica, no desprende al raspado, bordes definidos asociados a mucosa eritematosa. En dorsal de hemilengua derecha, en tercio medio hay otra lesión similar (3x0,7 cm). Se realizó biopsia incisional: zona derecha presenta epitelio hiperplásico recubierto por gruesa capa de queratina e izquierda presenta epitelio hiperqueratinizado, esfumamiento de membrana basal y banda de linfocitos subepitelial, diagnóstico histopatológico de hiperqueratosis. Se indica eliminación de hábito tabáquico y controles periódicos.Relevancia Clínica: La LVP afecta predominantemente a mujeres mayores de 60 años. Progresa desde una lesión única a multifocales con crecimiento exofítico, aspecto verrucoso y áreas queratinizadas. La histología muestra variadas características, desde hiperqueratosis en las primeras etapas, acantosis y atipia, que luego pueden progresar a hiperplasia verrugosa, carcinoma verrugoso y, finalmente, carcinoma de células escamosas. No existe un protocolo terapéutico eficaz, pues presenta alta recurrencia, volviéndose fundamental evitar factores de riesgo y controlar periódicamente.Conclusión: La LVP es multifocal, de alta recurrencia y potencial de malignización. Fundamental diagnosticarla precozmente y seguimiento adecuado pues inicialmente puede presentarse como hiperqueratosis, además de eliminar los factores de riesgo, realizar controles y biopsias periódicas. | es-ES |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Universidad de Valparaíso | es-ES |
| dc.relation | https://revistas.uv.cl/index.php/asid/article/view/2654/2586 | |
| dc.rights | Derechos de autor 2020 Applied Sciences in Dentistry | es-ES |
| dc.source | Applied Sciences in Dentistry; Vol. 1 (2020): Supl. 1 | en-US |
| dc.source | Applied Sciences in Dentistry; Vol. 1 (2020): Supl. 1 | es-ES |
| dc.source | 0719-5761 | |
| dc.source | 0719-5761 | |
| dc.subject | Leukoplakia | en-US |
| dc.subject | proliferative verrucous leukoplakia | en-US |
| dc.subject | tobacco | en-US |
| dc.subject | Leucoplasia | es-ES |
| dc.subject | leucoplasia verrucosa proliferative | es-ES |
| dc.subject | tabaco | es-ES |
| dc.title | Differential Diagnosis of Proliferative Verrucous Leukoplakia in Tongue: Report of a Case | en-US |
| dc.title | Diagnóstico Diferencial de Leucoplasia Verrucosa Proliferativa en Lengua: Reporte de un Caso | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |
This item appears in the following Collection(s)
-
Applied Sciences in Dentistry
[0-9]{4}