Objective: To develop the nursing process for an adult patient with severe vancomycin red man admitted to a Critical Patient Unit of a Chilean public hospital. Case Presentation: This case report focuses on an adult patient diagnosed with Red Man Syndrome induced by vancomycin and hospitalized in an Intensive Care Unit. The patient had a history of chronic renal failure and a prior mild adverse reaction to the medication. The nursing process was applied, using Virginia Henderson's need theory as an assessment framework. Taxonomy II of the North American Nursing Diagnosis Association International (NANDA-I) and Linda Carpenito's Bifocal Clinical Practice Model were used for care planning. Discussion: Nurses play a pivotal role in the preparation and administration of medications. The nursing process is an effective tool for delivering care, preventing medication errors, and mitigating their potential consequences for patients. Conclusions: Implementing the nursing process in patients with Red Man Syndrome underscores the critical role of nurses in enhancing care quality, improving patient outcomes, and guiding care delivery. Additionally, it contributes to strengthening post-care quality of life.Objetivo: Desarrollar el proceso enfermero a una persona adulta con hombre rojo por vancomicina grave ingresada a una Unidad de Paciente Crítico de un hospital público chileno. Presentación del caso: Estudio de reporte de caso a persona adulta hospitalizada en Unidad de Cuidados Intensivos afectada por el síndrome de hombre rojo por Vancomicina con antecedentes de Insuficiencia renal crónica y reacción adversa al medicamento leve previo, a quien se le aplica el Proceso de enfermería, se utilizó cómo guía para la valoración la teoría de la satisfacción de las necesidades de Virginia Henderson y para la planificación del cuidado, la Taxonomía II de la North American Nursing Diagnosis Association International y el modelo de Práctica clínica Bifocal de Linda Carpenito. Discusión: las enfermeras cumplen un rol protagónico como responsables de la preparación y administración de los medicamentos. La aplicación del proceso de enfermería representa una herramienta eficaz para la provisión de cuidados que puede prevenir los errores de medicación y las posteriores consecuencias en las personas atendidas  Conclusiones: El desarrollo de este proceso de enfermería en usuarios que cursan con síndrome del hombre rojo aporta a evidenciar el rol de la enfermera en la mejora de la calidad de los cuidados, mejorar el pronóstico y puede representar una ayuda para guiar el proceso de cuidados y la calidad de vida posterior.Objective: To develop the nursing process for an adult patient with severe vancomycin red man admitted to a Critical Patient Unit of a Chilean public hospital. Case Presentation: This case report focuses on an adult patient diagnosed with Red Man Syndrome induced by vancomycin and hospitalized in an Intensive Care Unit. The patient had a history of chronic renal failure and a prior mild adverse reaction to the medication. The nursing process was applied, using Virginia Henderson's need theory as an assessment framework. Taxonomy II of the North American Nursing Diagnosis Association International (NANDA-I) and Linda Carpenito's Bifocal Clinical Practice Model were used for care planning. Discussion: Nurses play a pivotal role in the preparation and administration of medications. The nursing process is an effective tool for delivering care, preventing medication errors, and mitigating their potential consequences for patients. Conclusions: Implementing the nursing process in patients with Red Man Syndrome underscores the critical role of nurses in enhancing care quality, improving patient outcomes, and guiding care delivery. Additionally, it contributes to strengthening post-care quality of life.